Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.E578A

c.1733A>C

Surrounding Variants

1 paper

NM_138636.5

p.E578G

c.1733A>G

1 paper

NM_138636.5

p.F583L

c.1749C>A

1 paper

NM_138636.5

p.F583F

c.1749C>T

1 paper

NM_138636.5

p.V573I

c.1717G>A

3 papers

NM_138636.5

p.G572D

c.1715G>A

4 papers

NM_138636.5

p.G572V

c.1715G>T

1 paper

NM_138636.5

p.N585D

c.1753A>G

1 paper

NM_138636.5

p.F568S

c.1703T>C

1 paper

NM_138636.5

p.Y567*

c.1701T>A

1 paper

NM_138636.5

p.Y567*

c.1701T>G

1 paper

NM_138636.5

p.L591F

c.1773G>T

1 paper

NM_138636.5

p.D560G

c.1679A>G