Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.K608delFs

c.1824delG

Surrounding Variants

1 paper

NM_138636.5

p.S607R

c.1821C>A

1 paper

NM_138636.5

p.S607R

c.1821C>G

1 paper

NM_138636.5

p.S609P

c.1825T>C

1 paper

NM_138636.5

p.S607R

c.1819A>C

1 paper

NM_138636.5

p.L620_D621del2

c.1858_1862del6

1 paper

NM_138636.5

p.R619R

c.1857C>T

1 paper

NM_138636.5

p.L620I

c.1858C>A

1 paper

NM_138636.5

p.L620F

c.1858C>T

1 paper

NM_138636.5

p.W624*

c.1871G>A

2 papers

NM_138636.5

p.W624*

c.1872G>A

1 paper

NM_138636.5

p.N625Y

c.1873A>T

1 paper

NM_138636.5

p.L591F

c.1773G>T