Varaico: Literature-Extracted Genetic Variants

TLR8

232 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 276–323UCSCLeucine rich repeat

LRR_8aa 639–700UCSCLeucine rich repeat

LRR_8aa 712–774UCSCLeucine rich repeat

TIRaa 879–1039UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 8

HGNC Alias Symbols

CD288; hTLR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138636.5

p.F687S

c.2060T>C

Surrounding Variants

1 paper

NM_138636.5

p.F687C

c.2060T>G

1 paper

NM_138636.5

p.L684L

c.2052C>T

1 paper

NM_138636.5

p.E691G

c.2072A>G

1 paper

NM_138636.5

p.L692F

c.2076G>T

3 papers

NM_138636.5

p.N680K

c.2040C>G

1 paper

NM_138636.5

p.D694D

c.2082C>T

1 paper

NM_138636.5

p.F679S

c.2036T>C

1 paper

NM_138636.5

p.K677N

c.2031G>C

1 paper

NM_138636.5

p.K677N

c.2031G>T

1 paper

NM_138636.5

p.L701H

c.2102T>A

1 paper

NM_138636.5

p.N672D

c.2014A>G

1 paper

NM_138636.5

p.H670L

c.2009A>T