Varaico: Literature-Extracted Genetic Variants

TMPRSS15

193 papers

RefSeq Summary

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein i...

Pfam Domains

SEAaa 56–158UCSCSEA domain

Ldl_recept_aaa 182–221UCSCLow-density lipoprotein receptor domain class A

CUBaa 225–331UCSCCUB domain

MAMaa 347–503UCSCMAM domain, meprin/A5/mu

CUBaa 524–631UCSCCUB domain

Ldl_recept_aaa 641–677UCSCLow-density lipoprotein receptor domain class A

Gene Aliases

HGNC Name

transmembrane serine protease 15

HGNC Previous Symbol

PRSS7

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002772.3

p.Q902E

c.2704C>G

Surrounding Variants

2 papers

NM_002772.3

p.V903fs

c.2707_2708fs

1 paper

NM_002772.3

p.V903delFs

c.2707_2708delAC

1 paper

NM_002772.3

p.F904L

c.2710T>C

1 paper

NM_002772.3

p.F904L

c.2712T>G

1 paper

NM_002772.3

p.F904L

c.2712T>A

1 paper

NM_002772.3

p.P906S

c.2716C>T

1 paper

NM_002772.3

p.I895T

c.2684T>C

1 paper

NM_002772.3

p.A913V

c.2738C>T

1 paper

NM_002772.3

p.D890Splc

c.2668+1G>A

1 paper

NM_002772.3

p.T889K

c.2666C>A

1 paper

NM_002772.3

p.D876A

c.2627A>C

1 paper

NM_002772.3

p.I862_R872delFs

c.2584_2614del31