Varaico: Literature-Extracted Genetic Variants

Gene:TNFRSF4
Variant:p.F259I

TNFRSF4

111 papers

RefSeq Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout...

Pfam Domains

TNFR_c6aa 67–107UCSCTNFR/NGFR cysteine-rich region
TNFR_c6aa 128–166UCSCTNFR/NGFR cysteine-rich region

Gene Aliases

HGNC Name

TNF receptor superfamily member 4

HGNC Previous Symbol

TXGP1L

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003327.4
p.F259I
c.775T>A
Surrounding Variants
2 papers
NM_003327.4
p.Q267H
c.801G>T
2 papers
NM_003327.4
p.Q267H
c.801G>C
1 paper
NM_003327.4
p.G255Splc
c.764-39T>G
1 paper
NM_003327.4
p.*278*
c.833G>A
1 paper
NM_003327.4
p.P247H
c.740C>A
1 paper
NM_003327.4
p.R241Q
c.722G>A
1 paper
NM_003327.4
p.I233I
c.699C>T
1 paper
NM_003327.4
p.L231fs
c.691_692fs
1 paper
NM_003327.4
p.L231L
c.691C>T
1 paper
NM_003327.4
p.G229D
c.686G>A
1 paper
NM_003327.4
p.L227fs
c.679_680fs
1 paper
NM_003327.4
p.G226delFs
c.678delC
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."