TNF superfamily member 8

CD30LG

CD153

tumor necrosis factor (ligand) superfamily, member 8

Tumor necrosis factor ligand superfamily member 8

CD30 ligand

CD30-L

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

Varaico: Literature-Extracted Genetic Variants

TNFSF8

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol