target of myb1 like 2 membrane trafficking protein

target of myb1 (chicken) homolog-like 1

target of myb1-like 2 (chicken)

TOM1-like protein 2

Target of Myb-like protein 2

This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017].

Varaico: Literature-Extracted Genetic Variants

TOM1L2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Names