Varaico: Literature-Extracted Genetic Variants

TOP2A

335 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 78–224UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 266–430UCSCDNA gyrase B

Toprimaa 456–574UCSCToprim domain

TOPRIM_Caa 573–711UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 713–1172UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1430–1522UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II alpha

HGNC Previous Symbol

TOP2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001067.4

p.K1433fs

c.4297_4298fs

Surrounding Variants

1 paper

NM_001067.4

p.K1433T

c.4298A>C

2 papers

NM_001067.4

p.R1435fs

c.4303_4304fs

1 paper

NM_001067.4

p.R1435G

c.4303A>G

1 paper

NM_001067.4

p.R1435insFs

c.4303dupA

5 papers

NM_001067.4

p.R1435delFs

c.4303delT

2 papers

NM_001067.4

p.R1435fs

c.4303_4304fs

1 paper

NM_001067.4

p.G1431S

c.4291G>A

1 paper

NM_001067.4

p.A1436delFs

c.4306delC

1 paper

NM_001067.4

p.A1436fs

c.4306_4307fs

1 paper

NM_001067.4

p.T1430A

c.4288A>G

1 paper

NM_001067.4

p.T1429I

c.4286C>T

1 paper

NM_001067.4

p.T1427I

c.4280C>T