Varaico: Literature-Extracted Genetic Variants

TOP2A

335 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 78–224UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 266–430UCSCDNA gyrase B

Toprimaa 456–574UCSCToprim domain

TOPRIM_Caa 573–711UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 713–1172UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1430–1522UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II alpha

HGNC Previous Symbol

TOP2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001067.4

p.E1368D

c.4104A>T

Surrounding Variants

1 paper

NM_001067.4

p.E1368D

c.4104A>C

1 paper

NM_001067.4

p.L1369M

c.4105C>A

1 paper

NM_001067.4

p.K1370N

c.4110A>T

1 paper

NM_001067.4

p.K1370N

c.4110A>C

1 paper

NM_001067.4

p.S1365C

c.4093A>T

2 papers

NM_001067.4

p.S1365G

c.4093A>G

1 paper

NM_001067.4

p.K1363N

c.4089A>T

1 paper

NM_001067.4

p.K1363N

c.4089A>C

1 paper

NM_001067.4

p.S1374C

c.4120A>T

2 papers

NM_001067.4

p.S1374G

c.4120A>G

1 paper

NM_001067.4

p.S1374I

c.4121G>T

1 paper

NM_001067.4

p.V1376M

c.4126G>A