Varaico: Literature-Extracted Genetic Variants

TOP2A

335 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 78–224UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 266–430UCSCDNA gyrase B

Toprimaa 456–574UCSCToprim domain

TOPRIM_Caa 573–711UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 713–1172UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1430–1522UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II alpha

HGNC Previous Symbol

TOP2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001067.4

p.L784L

c.2352G>A

Surrounding Variants

1 paper

NM_001067.4

p.P786H

c.2357C>A

2 papers

NM_001067.4

p.L781I

c.2341C>A

1 paper

NM_001067.4

p.N780K

c.2340T>G

1 paper

NM_001067.4

p.N780K

c.2340T>A

2 papers

NM_001067.4

p.Q789*

c.2365C>T

1 paper

NM_001067.4

p.T792P

c.2374A>C

3 papers

NM_001067.4

p.N774I

c.2321A>T

1 paper

NM_001067.4

p.S800A

c.2398T>G

1 paper

NM_001067.4

p.I769V

c.2305A>G

1 paper

NM_001067.4

p.S802R

c.2404A>C

1 paper

NM_001067.4

p.S802R

c.2406T>G

1 paper

NM_001067.4

p.S802R

c.2406T>A