Varaico: Literature-Extracted Genetic Variants

TOP2A

335 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 78–224UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 266–430UCSCDNA gyrase B

Toprimaa 456–574UCSCToprim domain

TOPRIM_Caa 573–711UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 713–1172UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1430–1522UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II alpha

HGNC Previous Symbol

TOP2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_001067.4

p.K743N

c.2229G>C

Surrounding Variants

9 papers

NM_001067.4

p.K743N

c.2229G>T

1 paper

NM_001067.4

p.R740Q

c.2219G>A

1 paper

NM_001067.4

p.D738N

c.2212G>A

1 paper

NM_001067.4

p.R736L

c.2207G>T

1 paper

NM_001067.4

p.M754I

c.2262G>T

1 paper

NM_001067.4

p.M754I

c.2262G>C

1 paper

NM_001067.4

p.M754I

c.2262G>A

1 paper

NM_001067.4

p.S755F

c.2264C>T

1 paper

NM_001067.4

p.S756A

c.2266T>G

1 paper

NM_001067.4

p.R727I

c.2180G>T

1 paper

NM_001067.4

p.G760D

c.2279G>A

1 paper

NM_001067.4

p.L722F

c.2166G>T