Varaico: Literature-Extracted Genetic Variants

TOP2A

335 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 78–224UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 266–430UCSCDNA gyrase B

Toprimaa 456–574UCSCToprim domain

TOPRIM_Caa 573–711UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 713–1172UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1430–1522UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II alpha

HGNC Previous Symbol

TOP2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001067.4

p.N16K

c.48C>A

Surrounding Variants

1 paper

NM_001067.4

p.N16K

c.48C>G

1 paper

NM_001067.4

p.K17N

c.51A>T

1 paper

NM_001067.4

p.K17N

c.51A>C

1 paper

NM_001067.4

p.I18L

c.52A>C

1 paper

NM_001067.4

p.I18K

c.53T>A

1 paper

NM_001067.4

p.K19R

c.56A>G

1 paper

NM_001067.4

p.E11K

c.31G>A

1 paper

NM_001067.4

p.N10D

c.28A>G

1 paper

NM_001067.4

p.P8T

c.22C>A

1 paper

NM_001067.4

p.K25N

c.75G>T

1 paper

NM_001067.4

p.K25N

c.75G>C

1 paper

NM_001067.4

p.K26R

c.77A>G