Varaico: Literature-Extracted Genetic Variants

TOP2B

110 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 99–245UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 287–451UCSCDNA gyrase B

Toprimaa 477–595UCSCToprim domain

TOPRIM_Caa 594–732UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 734–1190UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1508–1610UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II beta

HGNC Alias Symbols

top2beta; TOPIIB

Papers

RefSeq ID

Protein change

DNA change

1–12 of 139 variants

3 papers

NM_001330700.2

p.K1563E

c.4687A>G

2 papers

NM_001068.3

p.H58Y

c.172C>T

2 papers

NM_001330700.2

p.H63Y

c.187C>T

2 papers

NM_001068.3

p.A485P

c.1453G>C

2 papers

NM_001330700.2

p.R553H

c.1658G>A

2 papers

NM_001330700.2

p.R656H

c.1967G>A

2 papers

NM_001330700.2

p.R757W

c.2269A>T

2 papers

NM_001330700.2

p.Y862C

c.2585A>G

1 paper

NM_001330700.2

p.G5D

c.14G>A

1 paper

NM_001330700.2

p.C7insFs

c.20dupG

1 paper

NM_001330700.2

p.G14A

c.41G>C

1 paper

NM_001330700.2

p.A19E

c.56C>A