Varaico: Literature-Extracted Genetic Variants

TOP2B

110 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 99–245UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 287–451UCSCDNA gyrase B

Toprimaa 477–595UCSCToprim domain

TOPRIM_Caa 594–732UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 734–1190UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1508–1610UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II beta

HGNC Alias Symbols

top2beta; TOPIIB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001330700.2

p.P1572L

c.4715C>T

Surrounding Variants

1 paper

NM_001330700.2

p.S1581*

c.4742C>G

1 paper

NM_001330700.2

p.S1581*

c.4742C>A

1 paper

NM_001330700.2

p.D1584H

c.4750G>C

1 paper

NM_001330700.2

p.S1613S

c.4839T>A

1 paper

NM_001068.3

p.D1613H

c.4837G>C

1 paper

NM_001330700.2

p.D1618E

c.4854T>A

1 paper

NM_001330700.2

p.T1567I

c.4700C>T

1 paper

NM_001330700.2

p.K1563_T1564del1

c.4688_4690delTTT

3 papers

NM_001330700.2

p.K1563E

c.4687A>G

1 paper

NM_001068.3

p.S1545A

c.4633T>G

1 paper

NM_001330700.2

p.S1526P

c.4576T>C

1 paper

NM_001330700.2

p.G1497Splc

c.4490-1G>A