Varaico: Literature-Extracted Genetic Variants

TOP2B

110 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 99–245UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 287–451UCSCDNA gyrase B

Toprimaa 477–595UCSCToprim domain

TOPRIM_Caa 594–732UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 734–1190UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1508–1610UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II beta

HGNC Alias Symbols

top2beta; TOPIIB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001330700.2

p.N758delFs

c.2273_2274delAT

Surrounding Variants

1 paper

NM_001330700.2

p.D759G

c.2276A>G

1 paper

NM_001330700.2

p.R757insFs

c.2270_2271ins13

1 paper

NM_001330700.2

p.R761C

c.2281C>T

2 papers

NM_001330700.2

p.R757W

c.2269A>T

1 paper

NM_001330700.2

p.F755L

c.2265C>G

1 paper

NM_001330700.2

p.F755L

c.2265C>A

1 paper

NM_001330700.2

p.F755L

c.2263T>C

1 paper

NM_001330700.2

p.K764N

c.2292A>T

1 paper

NM_001330700.2

p.K764N

c.2292A>C

1 paper

NM_001330700.2

p.G746S

c.2236G>A

1 paper

NM_001330700.2

p.A773A

c.2319T>G

1 paper

NM_001330700.2

p.E774K

c.2320G>A