Varaico: Literature-Extracted Genetic Variants

TOP2B

110 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 99–245UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 287–451UCSCDNA gyrase B

Toprimaa 477–595UCSCToprim domain

TOPRIM_Caa 594–732UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 734–1190UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1508–1610UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II beta

HGNC Alias Symbols

top2beta; TOPIIB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001330700.2

p.P737L

c.2210C>T

NM_001068.3

p.P732L

c.2195C>T

Surrounding Variants

1 paper

NM_001068.3

p.L721F

c.2161C>T

1 paper

NM_001330700.2

p.A669T

c.2005G>A

1 paper

NM_001068.3

p.Y656F

c.1967A>T

2 papers

NM_001068.3

p.R651H

c.1952G>A

NM_001330700.2

p.R656H

c.1967G>A

1 paper

NM_001068.3

p.R651C

c.1951C>T

1 paper

NM_001330700.2

p.A650T

c.1948G>A

1 paper

NM_001330700.2

p.K646N

c.1938G>T

1 paper

NM_001330700.2

p.K646N

c.1938G>C

1 paper

NM_001330700.2

p.K646E

c.1936A>G

1 paper

NM_001330700.2

p.S640C

c.1918A>T

2 papers

NM_001068.3

p.G633S

c.1897G>A

NM_001330700.2

p.G638S

c.1912G>A

1 paper

NM_001330700.2

p.G746S

c.2236G>A