Varaico: Literature-Extracted Genetic Variants

TOP2B

110 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 99–245UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 287–451UCSCDNA gyrase B

Toprimaa 477–595UCSCToprim domain

TOPRIM_Caa 594–732UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 734–1190UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1508–1610UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II beta

HGNC Alias Symbols

top2beta; TOPIIB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001330700.2

p.H519H

c.1557T>C

Surrounding Variants

2 papers

NM_001068.3

p.A485P

c.1453G>C

2 papers

NM_001068.3

p.S483L

c.1448C>T

NM_001330700.2

p.S488L

c.1463C>T

1 paper

NM_001068.3

p.D479delFs

c.1435_1436delTC

1 paper

NM_001330700.2

p.E475D

c.1425G>T

1 paper

NM_001330700.2

p.E475D

c.1425G>C

2 papers

NM_001068.3

p.G465G

c.1395T>A

NM_001330700.2

p.G470G

c.1410T>A

2 papers

NM_001330700.2

p.G470D

c.1409G>A

NM_001068.3

p.G465D

c.1394G>A

2 papers

NM_001330700.2

p.R553H

c.1658G>A

1 paper

NM_001330700.2

p.K461delFs

c.1382_1383delTT

1 paper

NM_001330700.2

p.K461R

c.1382A>G

1 paper

NM_001330700.2

p.K457R

c.1370A>G

1 paper

NM_001068.3

p.C443S

c.1327T>A