Varaico: Literature-Extracted Genetic Variants

TOP2B

110 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation...

Pfam Domains

HATPase_caa 99–245UCSCHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase

DNA_gyraseBaa 287–451UCSCDNA gyrase B

Toprimaa 477–595UCSCToprim domain

TOPRIM_Caa 594–732UCSCC-terminal associated domain of TOPRIM

DNA_topoisoIVaa 734–1190UCSCDNA gyrase/topoisomerase IV, subunit A

DTHCTaa 1508–1610UCSCDTHCT (NUC029) region

Gene Aliases

HGNC Name

DNA topoisomerase II beta

HGNC Alias Symbols

top2beta; TOPIIB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001330700.2

p.F106L

c.316T>C

Surrounding Variants

1 paper

NM_001330700.2

p.G90R

c.268G>A

1 paper

NM_001330700.2

p.Y85H

c.253T>C

1 paper

NM_001068.3

p.M77fs

c.229_230fs

1 paper

NM_001330700.2

p.V111I

c.331G>A

1 paper

NM_001330700.2

p.P132A

c.394C>G

1 paper

NM_001068.3

p.Y66F

c.197A>T

1 paper

NM_001068.3

p.T65I

c.194C>T

1 paper

NM_001330700.2

p.R67C

c.199C>T

4 papers

NM_001068.3

p.H58Y

c.172C>T

NM_001330700.2

p.H63Y

c.187C>T

1 paper

NM_001330700.2

p.T59A

c.175A>G

1 paper

NM_001330700.2

p.V51I

c.151G>A

1 paper

NM_001330700.2

p.S46L

c.137C>T