Varaico: Literature-Extracted Genetic Variants

TOP3A

119 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single stran...

Pfam Domains

Toprimaa 36–181UCSCToprim domain

Topoisom_bacaa 195–607UCSCDNA topoisomerase

Zn_ribbon_Top1aa 655–694UCSCTopoisomerase DNA binding C4 zinc finger

Zn_ribbon_GRFaa 811–852UCSCGRF zinc finger

Gene Aliases

HGNC Name

DNA topoisomerase III alpha

HGNC Previous Symbol

TOP3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004618.5

p.G674R

c.2020G>A

Surrounding Variants

1 paper

NM_004618.5

p.G674R

c.2020G>C

1 paper

NM_004618.5

p.P706A

c.2116C>G

1 paper

NM_004618.5

p.G674R

c.2020G>A

1 paper

NM_004618.5

p.K668R

c.2003A>G

1 paper

NM_004618.5

p.D664A

c.1991A>C

1 paper

NM_004618.5

p.C658Y

c.1973G>A

1 paper

NM_004618.5

p.R656G

c.1966A>G

1 paper

NM_004618.5

p.F635fs

c.1903_1904fs

1 paper

NM_004618.5

p.L631L

c.1891T>C

1 paper

NM_004618.5

p.E629D

c.1887G>T

1 paper

NM_004618.5

p.E629D

c.1887G>C

2 papers

NM_004618.5

p.E629K

c.1885G>A