Varaico: Literature-Extracted Genetic Variants

TOP3A

119 papers

RefSeq Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single stran...

Pfam Domains

Toprimaa 36–181UCSCToprim domain

Topoisom_bacaa 195–607UCSCDNA topoisomerase

Zn_ribbon_Top1aa 655–694UCSCTopoisomerase DNA binding C4 zinc finger

Zn_ribbon_GRFaa 811–852UCSCGRF zinc finger

Gene Aliases

HGNC Name

DNA topoisomerase III alpha

HGNC Previous Symbol

TOP3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004618.5

p.M1L

c.1A>T

Surrounding Variants

1 paper

NM_004618.5

p.M1L

c.1A>C

1 paper

NM_004618.5

p.M1I

c.3G>T

1 paper

NM_004618.5

p.M1insFs

c.2dupT

1 paper

NM_004618.5

p.M1fs

c.1_2fs

1 paper

NM_004618.5

p.M1I

c.3G>C

1 paper

NM_004618.5

p.M1I

c.3G>A

1 paper

NM_004618.5

p.Y8N

c.22T>A

1 paper

NM_004618.5

p.R11L

c.32G>T

1 paper

NM_004618.5

p.V33G

c.98T>G

1 paper

NM_004618.5

p.K35N

c.105A>T

1 paper

NM_004618.5

p.K35N

c.105A>C

3 papers

NM_004618.5

p.L37V

c.109C>G