Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

1–12 of 10202 variants

3558 papers

NM_000546.6

p.R175H

c.524G>A

3215 papers

NM_000546.6

p.R273H

c.818G>A

2446 papers

NM_000546.6

p.R248Q

c.743G>A

2232 papers

NM_000546.6

p.R248W

c.742C>T

1705 papers

NM_000546.6

p.R273C

c.817C>T

1608 papers

NM_000546.6

p.Y220C

c.659A>G

1517 papers

NM_000546.6

p.R282W

c.844C>T

1357 papers

NM_000546.6

p.G245S

c.733G>A

1106 papers

NM_000546.6

p.R249S

c.747G>T

1100 papers

NM_000546.6

p.R249S

c.747G>C

916 papers

NM_000546.6

p.R213*

c.637C>T

852 papers

NM_000546.6

p.P72R

c.215C>G