Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.D393E

c.1179C>G

Surrounding Variants

1 paper

NM_000546.6

p.D393_*394insFs

c.1179_1180insT

9 papers

NM_000546.6

p.D393fs

c.1177_1178fs

3 papers

NM_000546.6

p.D393E

c.1179C>A

1 paper

NM_000546.6

p.D393insFs

c.1179dupC

1 paper

NM_000546.6

p.*394G

c.1180T>G

2 papers

NM_000546.6

p.*394R

c.1180T>C

1 paper

NM_000546.6

p.*394R

c.1180T>A

1 paper

NM_000546.6

p.S392_D393delFs

c.1176_1179del4

1 paper

NM_000546.6

p.T387_D393delFs

c.1161_1179del19

2 papers

NM_000546.6

p.D393V

c.1178A>T

4 papers

NM_000546.6

p.D393G

c.1178A>G

2 papers

NM_000546.6

p.D393A

c.1178A>C