Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.D393G

c.1178A>G

Surrounding Variants

2 papers

NM_000546.6

p.D393V

c.1178A>T

2 papers

NM_000546.6

p.D393A

c.1178A>C

2 papers

NM_000546.6

p.D393delFs

c.1177delC

10 papers

NM_000546.6

p.D393Y

c.1177G>T

2 papers

NM_000546.6

p.D393insFs

c.1177_1178insT

2 papers

NM_000546.6

p.D393_*394insC

c.1177_1181ins3

4 papers

NM_000546.6

p.S392insFs

c.1176dupA

10 papers

NM_000546.6

p.D393H

c.1177G>C

15 papers

NM_000546.6

p.D393N

c.1177G>A

1 paper

NM_000546.6

p.S392delFs

c.1176delT

1 paper

NM_000546.6

p.P390_S392del3

c.1168_1175del9

3 papers

NM_000546.6

p.D393E

c.1179C>G