Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.D391D

c.1173C>T

Surrounding Variants

4 papers

NM_000546.6

p.D391E

c.1173C>G

1 paper

NM_000546.6

p.D391insFs

c.1172dupA

3 papers

NM_000546.6

p.D391E

c.1173C>A

1 paper

NM_000546.6

p.G389_D391delFs

c.1165_1172del8

1 paper

NM_000546.6

p.E388_P390del3

c.1162_1169del9

1 paper

NM_000546.6

p.S392_D393insG

c.1174_1178ins3

40 papers

NM_000546.6

p.S392A

c.1174T>G

6 papers

NM_000546.6

p.S392P

c.1174T>C

1 paper

NM_000546.6

p.S392T

c.1174T>A

2 papers

NM_000546.6

p.P390_D391del2

c.1168_1172del6

1 paper

NM_000546.6

p.G389_D391del3

c.1165_1172del9

3 papers

NM_000546.6

p.D391V

c.1172A>T