Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.D391V

c.1172A>T

Surrounding Variants

3 papers

NM_000546.6

p.D391G

c.1172A>G

4 papers

NM_000546.6

p.D391A

c.1172A>C

1 paper

NM_000546.6

p.G389_P390del2

c.1165_1169del6

3 papers

NM_001126115.2

p.D259Y

c.775G>T

NM_000546.6

p.D391Y

c.1171G>T

1 paper

NM_000546.6

p.D391_S392insG

c.1171_1175ins3

1 paper

NM_000546.6

p.D391_S392ins4

c.1171_1175ins12

3 papers

NM_000546.6

p.D391H

c.1171G>C

5 papers

NM_000546.6

p.D391N

c.1171G>A

1 paper

NM_000546.6

p.T387_P390del4

c.1159_1169del12

1 paper

NM_000546.6

p.D391D

c.1173C>T

4 papers

NM_000546.6

p.D391E

c.1173C>G

1 paper

NM_000546.6

p.D391insFs

c.1172dupA