Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.P390R

c.1169C>G

Surrounding Variants

3 papers

NM_000546.6

p.P390L

c.1169C>T

1 paper

NM_000546.6

p.P390H

c.1169C>A

4 papers

NM_000546.6

p.P390fs

c.1168_1169fs

3 papers

NM_000546.6

p.P390delFs

c.1169delG

2 papers

NM_000546.6

p.P390Fs

c.1169_1170delinsAFs

9 papers

NM_000546.6

p.P390fs

c.1168_1169fs

6 papers

NM_000546.6

p.P390S

c.1168C>T

1 paper

NM_000546.6

p.P390A

c.1168C>G

1 paper

NM_000546.6

p.P390_D391insT

c.1168_1172ins3

4 papers

NM_000546.6

p.P390T

c.1168C>A

1 paper

NM_000546.6

p.G389delFs

c.1167delC

1 paper

NM_000546.6

p.G389delFs

c.1166_1167delCC