Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G389delFs

c.1167delC

Surrounding Variants

9 papers

NM_000546.6

p.P390fs

c.1168_1169fs

6 papers

NM_000546.6

p.P390S

c.1168C>T

1 paper

NM_000546.6

p.P390A

c.1168C>G

1 paper

NM_000546.6

p.P390_D391insT

c.1168_1172ins3

4 papers

NM_000546.6

p.P390T

c.1168C>A

1 paper

NM_000546.6

p.G389delFs

c.1166_1167delCC

1 paper

NM_000546.6

p.T387_G389del3

c.1159_1166del9

1 paper

NM_000546.6

p.G389G

c.1167G>T

1 paper

NM_000546.6

p.G389_P390insFs

c.1167_1168insT

1 paper

NM_000546.6

p.G389fs

c.1165_1166fs

1 paper

NM_000546.6

p.G389G

c.1167G>C

1 paper

NM_000546.6

p.T387_G389delFs

c.1160_1166del7