Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.G389_P390insA

c.1165_1169ins3

Surrounding Variants

10 papers

NM_000546.6

p.G389W

c.1165G>T

11 papers

NM_000546.6

p.G389R

c.1165G>C

11 papers

NM_000546.6

p.G389R

c.1165G>A

1 paper

NM_000546.6

p.T387_E388del2

c.1159_1163del6

1 paper

NM_000546.6

p.K386_E388del3

c.1156_1163del9

1 paper

NM_000546.6

p.K381_E388del8

c.1141_1163del24

3 papers

NM_000546.6

p.G389V

c.1166G>T

4 papers

NM_000546.6

p.G389A

c.1166G>C

11 papers

NM_000546.6

p.G389E

c.1166G>A

1 paper

NM_000546.6

p.E388del1

c.1162_1163delTTC

3 papers

NM_000546.6

p.E388D

c.1164A>T

1 paper

NM_000546.6

p.E388E

c.1164A>G