Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T387fs

c.1159_1160fs

Surrounding Variants

1 paper

NM_000546.6

p.T387T

c.1161A>T

2 papers

NM_000546.6

p.T387T

c.1161A>G

1 paper

NM_000546.6

p.E388*

c.1162G>T

2 papers

NM_000546.6

p.E388insFs

c.1162_1163insT

1 paper

NM_000546.6

p.E388_G389insG

c.1162_1166ins3

3 papers

NM_000546.6

p.E388Q

c.1162G>C

4 papers

NM_000546.6

p.E388K

c.1162G>A

1 paper

NM_000546.6

p.T387del1

c.1159_1160delTGT

2 papers

NM_000546.6

p.F385_T387del3

c.1153_1160del9

1 paper

NM_000546.6

p.M384_T387del4

c.1150_1160del12

2 papers

NM_000546.6

p.T387I

c.1160C>T

8 papers

NM_000546.6

p.T387R

c.1160C>G