Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T387fs

c.1159_1160fs

Surrounding Variants

3 papers

NM_000546.6

p.T387S

c.1159A>T

NM_001126115.2

p.T255S

c.763A>T

3 papers

NM_000546.6

p.T387A

c.1159A>G

1 paper

NM_000546.6

p.T387P

c.1159A>C

1 paper

NM_000546.6

p.T387_E388insT

c.1159_1163ins3

1 paper

NM_000546.6

p.F385_K386del2

c.1153_1157del6

6 papers

NM_000546.6

p.K386N

c.1158G>T

6 papers

NM_000546.6

p.K386N

c.1158G>C

2 papers

NM_000546.6

p.T387I

c.1160C>T

8 papers

NM_000546.6

p.T387R

c.1160C>G

1 paper

NM_000546.6

p.T387K

c.1160C>A

1 paper

NM_000546.6

p.T387delFs

c.1159delT

1 paper

NM_000546.6

p.M384_K386del3

c.1150_1157del9