Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.F385S

c.1154T>C

Surrounding Variants

2 papers

NM_000546.6

p.F385C

c.1154T>G

2 papers

NM_000546.6

p.F385Y

c.1154T>A

2 papers

NM_000546.6

p.F385_K386insT

c.1153_1157ins3

3 papers

NM_001126118.2

p.F346V

c.1036T>G

NM_000546.6

p.F385V

c.1153T>G

9 papers

NM_001126118.2

p.F346L

c.1036T>C

NM_000546.6

p.F385L

c.1153T>C

2 papers

NM_000546.6

p.F385I

c.1153T>A

1 paper

NM_000546.6

p.M384_F385Fs

c.1151_1153delinsGFs

1 paper

NM_000546.6

p.L383_M384del2

c.1147_1151del6

2 papers

NM_000546.6

p.K382_M384del3

c.1144_1151del9

1 paper

NM_000546.6

p.F385F

c.1155C>T

8 papers

NM_000546.6

p.F385L

c.1155C>G

1 paper

NM_000546.6

p.F385insFs

c.1154dupT