Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.M384L

c.1150A>T

Surrounding Variants

1 paper

NM_000546.6

p.M384fs

c.1150_1151fs

10 papers

NM_000546.6

p.M384V

c.1150A>G

NM_001126115.2

p.M252V

c.754A>G

3 papers

NM_000546.6

p.M384L

c.1150A>C

1 paper

NM_000546.6

p.M384_F385insA

c.1150_1154ins3

1 paper

NM_000546.6

p.S378_L383delFs

c.1134_1149del16

1 paper

NM_000546.6

p.M384insFs

c.1150dupA

4 papers

NM_000546.6

p.M384R

c.1151T>G

14 papers

NM_000546.6

p.M384T

c.1151T>C

5 papers

NM_000546.6

p.M384K

c.1151T>A

1 paper

NM_000546.6

p.L383_M384delFs

c.1147_1150del4

4 papers

NM_000546.6

p.K382_L383del2

c.1144_1148del6

4 papers

NM_000546.6

p.K381_L383del3

c.1141_1148del9