Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.K382insFs

c.1146dupA

Surrounding Variants

8 papers

NM_000546.6

p.L383F

c.1147C>T

1 paper

NM_000546.6

p.L383V

c.1147C>G

1 paper

NM_000546.6

p.L383_M384insG

c.1147_1151ins3

3 papers

NM_000546.6

p.L383I

c.1147C>A

5 papers

NM_000546.6

p.L383fs

c.1147_1148fs

35 papers

NM_000546.6

p.K382delFs

c.1146delT

1 paper

NM_000546.6

p.K382del1

c.1144_1145delTTT

3 papers

NM_000546.6

p.L383R

c.1148T>G

3 papers

NM_000546.6

p.L383P

c.1148T>C

2 papers

NM_000546.6

p.L383H

c.1148T>A

2 papers

NM_000546.6

p.L383delFs

c.1147delG

2 papers

NM_000546.6

p.K382N

c.1146A>T