Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

16 papers

NM_000546.6

p.K381R

c.1142A>G

NM_001126118.2

p.K342R

c.1025A>G

Surrounding Variants

4 papers

NM_000546.6

p.K381I

c.1142A>T

5 papers

NM_000546.6

p.K381T

c.1142A>C

NM_001126118.2

p.K342T

c.1025A>C

7 papers

NM_000546.6

p.K381N

c.1143A>T

4 papers

NM_000546.6

p.K381*

c.1141A>T

7 papers

NM_001126115.2

p.K249E

c.745A>G

NM_000546.6

p.K381E

c.1141A>G

1 paper

NM_001126118.2

p.K342K

c.1026A>G

11 papers

NM_000546.6

p.K381Q

c.1141A>C

6 papers

NM_000546.6

p.K381N

c.1143A>C

1 paper

NM_000546.6

p.H380insFs

c.1140dupT

1 paper

NM_000546.6

p.K381insFs

c.1141_1142insG

1 paper

NM_000546.6

p.K381_K382insA

c.1141_1145ins3

1 paper

NM_000546.6

p.H380delFs

c.1140delA