Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_001126115.2

p.K249E

c.745A>G

NM_000546.6

p.K381E

c.1141A>G

Surrounding Variants

4 papers

NM_000546.6

p.K381*

c.1141A>T

11 papers

NM_000546.6

p.K381Q

c.1141A>C

1 paper

NM_000546.6

p.H380insFs

c.1140dupT

1 paper

NM_000546.6

p.K381insFs

c.1141_1142insG

1 paper

NM_000546.6

p.K381_K382insA

c.1141_1145ins3

1 paper

NM_000546.6

p.H380delFs

c.1140delA

1 paper

NM_000546.6

p.R379_H380del2

c.1135_1139del6

1 paper

NM_000546.6

p.Q375_H380delFs

c.1125_1140del16

1 paper

NM_000546.6

p.T377_H380insFs

c.1129_1139dup11

2 papers

NM_000546.6

p.H380Q

c.1140T>G

2 papers

NM_000546.6

p.H380Q

c.1140T>A

1 paper

NM_000546.6

p.H380delFs

c.1139delT