Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

27 papers

NM_000546.6

p.Q375*

c.1123C>T

Surrounding Variants

3 papers

NM_000546.6

p.Q375fs

c.1123_1124fs

3 papers

NM_000546.6

p.Q375E

c.1123C>G

1 paper

NM_000546.6

p.Q375_S376insAA

c.1123_1127ins6

1 paper

NM_000546.6

p.Q375_S376insGTC

c.1123_1127ins9

1 paper

NM_000546.6

p.Q375_S376ins5

c.1123_1127ins15

10 papers

NM_000546.6

p.Q375K

c.1123C>A

1 paper

NM_000546.6

p.G374fs

c.1120_1121fs

2 papers

NM_000546.6

p.G374delFs

c.1121delC

1 paper

NM_000546.6

p.Q375L

c.1124A>T

6 papers

NM_000546.6

p.Q375R

c.1124A>G

1 paper

NM_000546.6

p.Q375P

c.1124A>C

2 papers

NM_000546.6

p.Q375delFs

c.1123delG