Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

17 papers

NM_000546.6

p.G374R

c.1120G>C

Surrounding Variants

5 papers

NM_000546.6

p.G374fs

c.1120_1121fs

6 papers

NM_000546.6

p.G374C

c.1120G>T

1 paper

NM_000546.6

p.G374_Q375ins4

c.1120_1124ins12

1 paper

NM_000546.6

p.G374_Q375ins6

c.1120_1124ins18

11 papers

NM_000546.6

p.G374S

c.1120G>A

4 papers

NM_000546.6

p.K373N

c.1119G>T

2 papers

NM_000546.6

p.G374V

c.1121G>T

1 paper

NM_000546.6

p.G374insFs

c.1121_1122insT

6 papers

NM_000546.6

p.K373fs

c.1117_1118fs

NM_001126115.2

p.K241fs

c.721_722fs

1 paper

NM_000546.6

p.K372insFs

c.1114_1115insA

3 papers

NM_000546.6

p.G374A

c.1121G>C

3 papers

NM_000546.6

p.K373N

c.1119G>C