Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_000546.6

p.S371F

c.1112C>T

Surrounding Variants

5 papers

NM_000546.6

p.S371C

c.1112C>G

3 papers

NM_000546.6

p.S371Y

c.1112C>A

3 papers

NM_000546.6

p.S371_K372insC

c.1111_1115ins3

3 papers

NM_000546.6

p.S371A

c.1111T>G

3 papers

NM_000546.6

p.S371P

c.1111T>C

1 paper

NM_000546.6

p.S371T

c.1111T>A

1 paper

NM_000546.6

p.H368_K370del3

c.1102_1109del9

4 papers

NM_001126118.2

p.S332S

c.996C>T

NM_000546.6

p.S371S

c.1113C>T

3 papers

NM_000546.6

p.S371S

c.1113C>G

1 paper

NM_000546.6

p.S371S

c.1113C>A

3 papers

NM_000546.6

p.K370N

c.1110G>T

3 papers

NM_000546.6

p.K370N

c.1110G>C