Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.H368Q

c.1104C>A

Surrounding Variants

3 papers

NM_000546.6

p.H368H

c.1104C>T

NM_001126118.2

p.H329H

c.987C>T

7 papers

NM_000546.6

p.H368Q

c.1104C>G

1 paper

NM_000546.6

p.L369fs

c.1105_1106fs

4 papers

NM_000546.6

p.L369L

c.1105C>T

2 papers

NM_000546.6

p.L369V

c.1105C>G

3 papers

NM_000546.6

p.L369M

c.1105C>A

2 papers

NM_000546.6

p.H368L

c.1103A>T

3 papers

NM_001126115.2

p.H236R

c.707A>G

NM_000546.6

p.H368R

c.1103A>G

3 papers

NM_000546.6

p.H368P

c.1103A>C

1 paper

NM_000546.6

p.S367insFs

c.1101dupC

1 paper

NM_000546.6

p.L369R

c.1106T>G

6 papers

NM_000546.6

p.L369P

c.1106T>C