Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S367Splc

c.1100+1G>T

Surrounding Variants

3 papers

NM_000546.6

p.S367Splc

c.1100+1G>C

3 papers

NM_000546.6

p.S367Splc

c.1100+1G>A

2 papers

NM_000546.6

p.S367Splc

c.1100+2T>G

2 papers

NM_000546.6

p.S367Splc

c.1100+2T>C

1 paper

NM_000546.6

p.S367Splc

c.1100+2T>A

3 papers

NM_000546.6

p.S367delFs

c.1100delC

1 paper

NM_000546.6

p.S367I

c.1100G>T

1 paper

NM_000546.6

p.S367T

c.1100G>C

5 papers

NM_000546.6

p.S367N

c.1100G>A

2 papers

NM_000546.6

p.S367Splc

c.1100+3G>C

2 papers

NM_000546.6

p.S367fs

c.1099_1100fs

2 papers

NM_000546.6

p.S367C

c.1099A>T