Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.S366F

c.1097C>T

Surrounding Variants

4 papers

NM_000546.6

p.S366C

c.1097C>G

1 paper

NM_000546.6

p.S366Y

c.1097C>A

41 papers

NM_000546.6

p.S366A

c.1096T>G

4 papers

NM_000546.6

p.S366P

c.1096T>C

5 papers

NM_001126115.2

p.S234T

c.700T>A

NM_000546.6

p.S366T

c.1096T>A

1 paper

NM_000546.6

p.S362_H365del4

c.1084_1094del12

1 paper

NM_000546.6

p.P359_S366Fs

c.1076_1096delinsTGTAAGGFs

2 papers

NM_000546.6

p.P359_H365del0

c.1075_1095del21

1 paper

NM_000546.6

p.S366S

c.1098C>T

1 paper

NM_000546.6

p.S366delins

c.1097_1098delinsGG

1 paper

NM_000546.6

p.H365_S366delFs

c.1093_1096del4

2 papers

NM_000546.6

p.S367fs

c.1099_1100fs