Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.H365L

c.1094A>T

Surrounding Variants

8 papers

NM_000546.6

p.H365R

c.1094A>G

2 papers

NM_000546.6

p.H365P

c.1094A>C

26 papers

NM_000546.6

p.H365Y

c.1093C>T

3 papers

NM_000546.6

p.H365H

c.1095C>T

3 papers

NM_000546.6

p.H365Q

c.1095C>G

3 papers

NM_000546.6

p.H365D

c.1093C>G

2 papers

NM_000546.6

p.H365insFs

c.1093_1094insG

3 papers

NM_000546.6

p.H365fs

c.1093_1094fs

3 papers

NM_000546.6

p.H365Q

c.1095C>A

2 papers

NM_000546.6

p.H365N

c.1093C>A

1 paper

NM_000546.6

p.R363_A364del2

c.1087_1091del6

1 paper

NM_000546.6

p.G361_A364delFs

c.1082_1092del11