Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.A364V

c.1091C>T

Surrounding Variants

2 papers

NM_000546.6

p.A364G

c.1091C>G

3 papers

NM_000546.6

p.A364D

c.1091C>A

2 papers

NM_000546.6

p.R363delFs

c.1088delC

1 paper

NM_000546.6

p.G360_R363delFs

c.1078_1087del10

4 papers

NM_000546.6

p.A364S

c.1090G>T

1 paper

NM_000546.6

p.A364_H365insT

c.1090_1094ins3

5 papers

NM_000546.6

p.A364P

c.1090G>C

11 papers

NM_000546.6

p.A364T

c.1090G>A

1 paper

NM_000546.6

p.R363del1

c.1087_1089delCCT

1 paper

NM_000546.6

p.S362_R363del2

c.1084_1088del6

2 papers

NM_000546.6

p.R363S

c.1089G>T

1 paper

NM_000546.6

p.R363fs

c.1087_1088fs