Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R363M

c.1088G>T

Surrounding Variants

1 paper

NM_000546.6

p.R363T

c.1088G>C

12 papers

NM_000546.6

p.R363K

c.1088G>A

2 papers

NM_000546.6

p.R363S

c.1089G>T

1 paper

NM_000546.6

p.R363fs

c.1087_1088fs

2 papers

NM_000546.6

p.R363S

c.1089G>C

1 paper

NM_000546.6

p.R363R

c.1089G>A

1 paper

NM_000546.6

p.R363W

c.1087A>T

12 papers

NM_000546.6

p.R363G

c.1087A>G

1 paper

NM_000546.6

p.G360_S362del3

c.1078_1085del9

4 papers

NM_000546.6

p.A364S

c.1090G>T

1 paper

NM_000546.6

p.A364_H365insT

c.1090_1094ins3

5 papers

NM_000546.6

p.A364P

c.1090G>C