Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.G361G

c.1083G>A

Surrounding Variants

3 papers

NM_000546.6

p.G361fs

c.1081_1082fs

5 papers

NM_000546.6

p.G361V

c.1082G>T

2 papers

NM_000546.6

p.G361A

c.1082G>C

13 papers

NM_000546.6

p.G361E

c.1082G>A

1 paper

NM_000546.6

p.L348_G361del0

c.1043_1081del39

5 papers

NM_000546.6

p.S362fs

c.1084_1085fs

8 papers

NM_000546.6

p.S362C

c.1084A>T

3 papers

NM_000546.6

p.S362G

c.1084A>G

4 papers

NM_000546.6

p.S362R

c.1084A>C

4 papers

NM_000546.6

p.G361insFs

c.1083dupG

10 papers

NM_000546.6

p.G361delFs

c.1083delC

1 paper

NM_000546.6

p.L348_G361del14

c.1042_1082del42