Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P359P

c.1077A>T

Surrounding Variants

4 papers

NM_000546.6

p.P359P

c.1077A>G

1 paper

NM_000546.6

p.P359insFs

c.1076dupC

1 paper

NM_000546.6

p.P359delFs

c.1075delG

5 papers

NM_000546.6

p.G360W

c.1078G>T

11 papers

NM_000546.6

p.G360R

c.1078G>C

12 papers

NM_000546.6

p.G360R

c.1078G>A

1 paper

NM_000546.6

p.G360fs

c.1078_1079fs

7 papers

NM_000546.6

p.P359delFs

c.1077delT

5 papers

NM_000546.6

p.P359L

c.1076C>T

4 papers

NM_000546.6

p.P359R

c.1076C>G

1 paper

NM_000546.6

p.P359Q

c.1076C>A

25 papers

NM_000546.6

p.G360V

c.1079G>T