Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.P359S

c.1075C>T

Surrounding Variants

2 papers

NM_000546.6

p.P359A

c.1075C>G

1 paper

NM_000546.6

p.P359T

c.1075C>A

1 paper

NM_000546.6

p.E358del1

c.1072_1073delCTC

7 papers

NM_000546.6

p.E358D

c.1074G>T

1 paper

NM_000546.6

p.E358insFs

c.1073dupA

7 papers

NM_000546.6

p.E358D

c.1074G>C

5 papers

NM_000546.6

p.P359L

c.1076C>T

4 papers

NM_000546.6

p.P359R

c.1076C>G

1 paper

NM_000546.6

p.P359Q

c.1076C>A

27 papers

NM_000546.6

p.E358V

c.1073A>T

1 paper

NM_000546.6

p.P359P

c.1077A>T

4 papers

NM_000546.6

p.P359P

c.1077A>G