Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

23 papers

NM_000546.6

p.E358K

c.1072G>A

NM_001126118.2

p.E319K

c.955G>A

Surrounding Variants

1 paper

NM_000546.6

p.E358*

c.1072G>T

1 paper

NM_000546.6

p.E358_P359ins4

c.1072_1076ins12

3 papers

NM_000546.6

p.E358Q

c.1072G>C

1 paper

NM_000546.6

p.E358fs

c.1072_1073fs

2 papers

NM_000546.6

p.K357N

c.1071G>T

2 papers

NM_000546.6

p.K357N

c.1071G>C

27 papers

NM_000546.6

p.E358V

c.1073A>T

2 papers

NM_000546.6

p.E358G

c.1073A>G

2 papers

NM_000546.6

p.E358A

c.1073A>C

1 paper

NM_000546.6

p.K357insFs

c.1071dupG

7 papers

NM_000546.6

p.E358D

c.1074G>T

1 paper

NM_000546.6

p.E358insFs

c.1073dupA