Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.A355V

c.1064C>T

Surrounding Variants

5 papers

NM_000546.6

p.A355G

c.1064C>G

2 papers

NM_000546.6

p.A355insFs

c.1064_1065insT

3 papers

NM_000546.6

p.A355D

c.1064C>A

2 papers

NM_000546.6

p.A355A

c.1065T>C

6 papers

NM_000546.6

p.A355S

c.1063G>T

5 papers

NM_000546.6

p.A355P

c.1063G>C

10 papers

NM_000546.6

p.A355T

c.1063G>A

7 papers

NM_000546.6

p.G356W

c.1066G>T

4 papers

NM_000546.6

p.Q354H

c.1062G>T

1 paper

NM_000546.6

p.G356_K357insA

c.1066_1070ins3

15 papers

NM_000546.6

p.G356R

c.1066G>C

4 papers

NM_000546.6

p.Q354H

c.1062G>C