Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

20 papers

NM_000546.6

p.Q354R

c.1061A>G

Surrounding Variants

2 papers

NM_000546.6

p.Q354L

c.1061A>T

3 papers

NM_000546.6

p.Q354P

c.1061A>C

1 paper

NM_000546.6

p.A353_Q354del1

c.1058_1060delGGG

2 papers

NM_000546.6

p.A347_Q354delFs

c.1041_1060del20

1 paper

NM_000546.6

p.R342_Q354del0

c.1025_1060del36

4 papers

NM_000546.6

p.Q354H

c.1062G>T

4 papers

NM_000546.6

p.Q354H

c.1062G>C

4 papers

NM_000546.6

p.Q354Q

c.1062G>A

1 paper

NM_000546.6

p.Q354fs

c.1060_1061fs

10 papers

NM_000546.6

p.Q354*

c.1060C>T

7 papers

NM_000546.6

p.Q354E

c.1060C>G

2 papers

NM_000546.6

p.Q354_A355insCA

c.1060_1064ins6